The Bromodomain Inhibitor, INCB057643, Targets both Cancer Cells and the Tumor Microenvironment in Two Preclinical Models of Pancreatic Cancer

The Bromodomain Inhibitor, INCB057643, Targets both Cancer Cells and the Tumor Microenvironment in Two Preclinical Models of Pancreatic Cancer

In pancreatic cancer the tumor microenvironment (TME) can account for up to 90% of the tumor mass. The TME drives essential functions in disease progression, invasion and metastasis. Tumor cells can use epigenetic modulation to evade immune recognition and shape the TME toward an immunosuppressive p...

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Bibliographic Details
Main Authors: Ana S. Leal, Phillip Liu, Teresa Krieger-Burke, Bruce Ruggeri, Karen T. Liby
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
pancreatic cancer
bromodomain inhibitors
inflammatory tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/13/1/96

Internet

https://www.mdpi.com/2072-6694/13/1/96

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