Characterization of the bipartite degron that regulates ubiquitin-independent degradation of thymidylate synthase

Characterization of the bipartite degron that regulates ubiquitin-independent degradation of thymidylate synthase

TS (thymidylate synthase) is a key enzyme in the de novo biosynthesis of dTMP, and is indispensable for DNA replication. Previous studies have shown that intracellular degradation of the human enzyme [hTS (human thymidylate synthase)] is mediated by the 26S proteasome, and occurs in a ubiquitin-inde...

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Bibliographic Details
Main Authors: Karen W. Barbour, Yang‑Yang Xing, Edsel A. Peña, Franklin G. Berger
Format: Article
Language:English
Published: Portland Press, Biochemical Society 2013-01-01
Series:Bioscience Reports
Subjects:
proteasome
relaxed purifying selection
thymidylate synthase
ubiquitin-independent
Online Access:http://www.bioscirep.org/bsr/033/e015/bsr033e015.htm

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http://www.bioscirep.org/bsr/033/e015/bsr033e015.htm

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