Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors
In fibrotic biliary disease, portal fibroblasts promote both biliary scarring and bile duct regeneration. Here, the authors report that the non-canonical Wnt-PCP signalling promotes bile duct scarring in mice, and inhibition of Wnt-ligands reduces the scarring without impairing regeneration.
Bibliographic Details
| Main Authors: |
D. H. Wilson,
E. J. Jarman,
R. P. Mellin,
M. L. Wilson,
S. H. Waddell,
P. Tsokkou,
N. T. Younger,
A. Raven,
S. R. Bhalla,
A. T. R. Noll,
S. W. Olde Damink,
F. G. Schaap,
P. Chen,
D. O. Bates,
J. M. Banales,
C. H. Dean,
D. J. Henderson,
O. J. Sansom,
T. J. Kendall,
L. Boulter |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2020-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-020-14283-3
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