Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

Non-canonical Wnt signalling regulates scarring in biliary disease via the planar cell polarity receptors

In fibrotic biliary disease, portal fibroblasts promote both biliary scarring and bile duct regeneration. Here, the authors report that the non-canonical Wnt-PCP signalling promotes bile duct scarring in mice, and inhibition of Wnt-ligands reduces the scarring without impairing regeneration.

Bibliographic Details
Main Authors: D. H. Wilson, E. J. Jarman, R. P. Mellin, M. L. Wilson, S. H. Waddell, P. Tsokkou, N. T. Younger, A. Raven, S. R. Bhalla, A. T. R. Noll, S. W. Olde Damink, F. G. Schaap, P. Chen, D. O. Bates, J. M. Banales, C. H. Dean, D. J. Henderson, O. J. Sansom, T. J. Kendall, L. Boulter
Format: Article
Language:English
Published: Nature Publishing Group 2020-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14283-3

Internet

https://doi.org/10.1038/s41467-020-14283-3

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