Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA
Circulating metabolites reflect human health and disease. Here, Kettunen et al. perform a genome-wide association study on 123 circulating metabolic traits and identify novel genetic loci influencing systemic metabolism. They also link new molecular pathways with a known cardiovascular risk factor L...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11122 |
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Article |
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DOAJ |
| language |
English |
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Article |
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DOAJ |
| author |
Johannes Kettunen Ayşe Demirkan Peter Würtz Harmen H.M. Draisma Toomas Haller Rajesh Rawal Anika Vaarhorst Antti J. Kangas Leo-Pekka Lyytikäinen Matti Pirinen René Pool Antti-Pekka Sarin Pasi Soininen Taru Tukiainen Qin Wang Mika Tiainen Tuulia Tynkkynen Najaf Amin Tanja Zeller Marian Beekman Joris Deelen Ko Willems van Dijk Tõnu Esko Jouke-Jan Hottenga Elisabeth M van Leeuwen Terho Lehtimäki Evelin Mihailov Richard J. Rose Anton J.M. de Craen Christian Gieger Mika Kähönen Markus Perola Stefan Blankenberg Markku J. Savolainen Aswin Verhoeven Jorma Viikari Gonneke Willemsen Dorret I. Boomsma Cornelia M. van Duijn Johan Eriksson Antti Jula Marjo-Riitta Järvelin Jaakko Kaprio Andres Metspalu Olli Raitakari Veikko Salomaa P. Eline Slagboom Melanie Waldenberger Samuli Ripatti Mika Ala-Korpela |
| spellingShingle |
Johannes Kettunen Ayşe Demirkan Peter Würtz Harmen H.M. Draisma Toomas Haller Rajesh Rawal Anika Vaarhorst Antti J. Kangas Leo-Pekka Lyytikäinen Matti Pirinen René Pool Antti-Pekka Sarin Pasi Soininen Taru Tukiainen Qin Wang Mika Tiainen Tuulia Tynkkynen Najaf Amin Tanja Zeller Marian Beekman Joris Deelen Ko Willems van Dijk Tõnu Esko Jouke-Jan Hottenga Elisabeth M van Leeuwen Terho Lehtimäki Evelin Mihailov Richard J. Rose Anton J.M. de Craen Christian Gieger Mika Kähönen Markus Perola Stefan Blankenberg Markku J. Savolainen Aswin Verhoeven Jorma Viikari Gonneke Willemsen Dorret I. Boomsma Cornelia M. van Duijn Johan Eriksson Antti Jula Marjo-Riitta Järvelin Jaakko Kaprio Andres Metspalu Olli Raitakari Veikko Salomaa P. Eline Slagboom Melanie Waldenberger Samuli Ripatti Mika Ala-Korpela Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA Nature Communications |
| author_facet |
Johannes Kettunen Ayşe Demirkan Peter Würtz Harmen H.M. Draisma Toomas Haller Rajesh Rawal Anika Vaarhorst Antti J. Kangas Leo-Pekka Lyytikäinen Matti Pirinen René Pool Antti-Pekka Sarin Pasi Soininen Taru Tukiainen Qin Wang Mika Tiainen Tuulia Tynkkynen Najaf Amin Tanja Zeller Marian Beekman Joris Deelen Ko Willems van Dijk Tõnu Esko Jouke-Jan Hottenga Elisabeth M van Leeuwen Terho Lehtimäki Evelin Mihailov Richard J. Rose Anton J.M. de Craen Christian Gieger Mika Kähönen Markus Perola Stefan Blankenberg Markku J. Savolainen Aswin Verhoeven Jorma Viikari Gonneke Willemsen Dorret I. Boomsma Cornelia M. van Duijn Johan Eriksson Antti Jula Marjo-Riitta Järvelin Jaakko Kaprio Andres Metspalu Olli Raitakari Veikko Salomaa P. Eline Slagboom Melanie Waldenberger Samuli Ripatti Mika Ala-Korpela |
| author_sort |
Johannes Kettunen |
| title |
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA |
| title_short |
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA |
| title_full |
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA |
| title_fullStr |
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA |
| title_full_unstemmed |
Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPA |
| title_sort |
genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of lpa |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2016-03-01 |
| description |
Circulating metabolites reflect human health and disease. Here, Kettunen et al. perform a genome-wide association study on 123 circulating metabolic traits and identify novel genetic loci influencing systemic metabolism. They also link new molecular pathways with a known cardiovascular risk factor Lp(a). |
| url |
https://doi.org/10.1038/ncomms11122 |
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doaj-efa9e82fc86e4339bfe2f9945de636862021-05-11T11:06:39ZengNature Publishing GroupNature Communications2041-17232016-03-01711910.1038/ncomms11122Genome-wide study for circulating metabolites identifies 62 loci and reveals novel systemic effects of LPAJohannes Kettunen0Ayşe Demirkan1Peter Würtz2Harmen H.M. Draisma3Toomas Haller4Rajesh Rawal5Anika Vaarhorst6Antti J. Kangas7Leo-Pekka Lyytikäinen8Matti Pirinen9René Pool10Antti-Pekka Sarin11Pasi Soininen12Taru Tukiainen13Qin Wang14Mika Tiainen15Tuulia Tynkkynen16Najaf Amin17Tanja Zeller18Marian Beekman19Joris Deelen20Ko Willems van Dijk21Tõnu Esko22Jouke-Jan Hottenga23Elisabeth M van Leeuwen24Terho Lehtimäki25Evelin Mihailov26Richard J. Rose27Anton J.M. de Craen28Christian Gieger29Mika Kähönen30Markus Perola31Stefan Blankenberg32Markku J. Savolainen33Aswin Verhoeven34Jorma Viikari35Gonneke Willemsen36Dorret I. Boomsma37Cornelia M. van Duijn38Johan Eriksson39Antti Jula40Marjo-Riitta Järvelin41Jaakko Kaprio42Andres Metspalu43Olli Raitakari44Veikko Salomaa45P. Eline Slagboom46Melanie Waldenberger47Samuli Ripatti48Mika Ala-Korpela49Computational Medicine, Faculty of Medicine, University of OuluDepartment of Human Genetics, Leiden University Medical CenterComputational Medicine, Faculty of Medicine, University of OuluDepartment of Biological Psychology, VU University AmsterdamEstonian Genome Center, University of TartuResearch Unit of Molecular Epidemiology, Helmholtz Zentrum MünchenDepartment of Molecular Epidemiology, Leiden University Medical CenterComputational Medicine, Faculty of Medicine, University of OuluDepartment of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere UniversityInstitute for Molecular Medicine (FIMM), University of HelsinkiDepartment of Biological Psychology, VU University AmsterdamNational Institute for Health and WelfareComputational Medicine, Faculty of Medicine, University of OuluDepartment of Medicine, Analytic and Translational Genetics Unit, Massachusetts General HospitalComputational Medicine, Faculty of Medicine, University of OuluComputational Medicine, Faculty of Medicine, University of OuluComputational Medicine, Faculty of Medicine, University of OuluDepartment of Epidemiology, Erasmus Medical CenterGerman Center for Cardiovascular Research (DZHK e.V.)Department of Molecular Epidemiology, Leiden University Medical CenterDepartment of Molecular Epidemiology, Leiden University Medical CenterDepartment of Human Genetics, Leiden University Medical CenterEstonian Genome Center, University of TartuDepartment of Biological Psychology, VU University AmsterdamDepartment of Epidemiology, Erasmus Medical CenterDepartment of Clinical Chemistry, Fimlab Laboratories, University of Tampere School of Medicine, Tampere UniversityEstonian Genome Center, University of TartuDepartment of Public Health, Hjelt Institute, University of HelsinkiDepartment of Geriatrics and Gerontology, Leiden University Medical CenterResearch Unit of Molecular Epidemiology, Helmholtz Zentrum MünchenDepartment of Clinical Physiology, University of Tampere and Tampere, University HospitalNational Institute for Health and WelfareGerman Center for Cardiovascular Research (DZHK e.V.)Biocenter Oulu, University of OuluCenter for Proteomics and Metabolomics, Leiden University Medical CenterDepartment of Medicine, University of Turku and Turku University HospitalDepartment of Biological Psychology, VU University AmsterdamDepartment of Biological Psychology, VU University AmsterdamDepartment of Epidemiology, Erasmus Medical CenterNational Institute for Health and WelfareNational Institute for Health and WelfareBiocenter Oulu, University of OuluInstitute for Molecular Medicine (FIMM), University of HelsinkiEstonian Genome Center, University of TartuResearch Centre of Applied and Preventive Cardiovascular Medicine, University of TurkuNational Institute for Health and WelfareDepartment of Molecular Epidemiology, Leiden University Medical CenterResearch Unit of Molecular Epidemiology, Helmholtz Zentrum MünchenNational Institute for Health and WelfareComputational Medicine, Faculty of Medicine, University of OuluCirculating metabolites reflect human health and disease. Here, Kettunen et al. perform a genome-wide association study on 123 circulating metabolic traits and identify novel genetic loci influencing systemic metabolism. They also link new molecular pathways with a known cardiovascular risk factor Lp(a).https://doi.org/10.1038/ncomms11122 |