Feedback Regulation of Cathepsin C by the Propeptide Dipeptides of Granzymes A and B

Granzymes A and B are activated by proteolytic removal of their N-terminal dipeptides by cathepsin C (dipeptidyl-peptidase I). However, the possible physiological role of the cleaved dipeptides Glu-Lys and Gly-Glu is not yet understood. In this study, adding either of the two dipeptides to NK-92 cel...

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Bibliographic Details
Main Authors: Janja Božič, Iztok Dolenc
Format: Article
Language:English
Published: Slovenian Chemical Society 2019-06-01
Series:Acta Chimica Slovenica
Subjects:
Online Access:https://journals.matheo.si/index.php/ACSi/article/view/5192