Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated

Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated

Abstract Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Mitochondria are essential for neuronal survival but the developmental timing and mechanistic importance of mitochondrial dysfunction in sporadic ALS (sALS) neurons is not full...

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Bibliographic Details
Main Authors: Tanisha Singh, Yuanyuan Jiao, Lisa M. Ferrando, Svitlana Yablonska, Fang Li, Emily C. Horoszko, David Lacomis, Robert M. Friedlander, Diane L. Carlisle
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97928-7

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https://doi.org/10.1038/s41598-021-97928-7

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