Ecto-5′-Nucleotidase (CD73) Regulates the Survival of CD8+ T Cells

Ecto-5′-Nucleotidase (CD73) Regulates the Survival of CD8+ T Cells

Ecto-5′-nucleotidase (CD73) is an enzyme present on the surface of tumor cells whose primary described function is the production of extracellular adenosine. Due to the immunosuppressive properties of adenosine, CD73 is being investigated as a target for new antitumor therapies. We and others have d...

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Bibliographic Details
Main Authors: Mariana V. Rosemblatt, Brian Parra-Tello, Pedro Briceño, Elizabeth Rivas-Yáñez, Suat Tucer, Juan Saavedra-Almarza, Pilar Hörmann, Brandon A. Martínez, Álvaro Lladser, Mario Rosemblatt, Caglar Cekic, María Rosa Bono, Daniela Sauma
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
CD73/NT5E
homeostatic
CD8+ T cell
antigenic activation
CD127 (IL7 receptor)
CD25
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.647058/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.647058/full

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