Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

Dengue virus (DENV) cycles between mosquito and mammalian hosts. To examine how DENV populations adapt to these different host environments, we used serial passage in human and mosquito cell lines and estimated fitness effects for all single-nucleotide variants in these populations using ultra-deep...

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Bibliographic Details
Main Authors: Patrick T Dolan, Shuhei Taguwa, Mauricio Aguilar Rangel, Ashley Acevedo, Tzachi Hagai, Raul Andino, Judith Frydman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-01-01
Series:eLife
Subjects:
dengue
population genomics
arbovirus
host adaptation
host-virus interactions
Online Access:https://elifesciences.org/articles/61921

Internet

https://elifesciences.org/articles/61921

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