Cyclovirobuxine D Induces Apoptosis and Mitochondrial Damage in Glioblastoma Cells Through ROS-Mediated Mitochondrial Translocation of Cofilin

Cyclovirobuxine D Induces Apoptosis and Mitochondrial Damage in Glioblastoma Cells Through ROS-Mediated Mitochondrial Translocation of Cofilin

BackgroundCyclovirobuxine D (CVBD), a steroidal alkaloid, has multiple pharmacological activities, including anti-cancer activity. However, the anti-cancer effect of CVBD on glioblastoma (GBM) has seldom been investigated. This study explores the activity of CVBD in inducing apoptosis of GBM cells,...

Full description

Bibliographic Details
Main Authors: Lin Zhang, Ruoqiu Fu, Dongyu Duan, Ziwei Li, Bin Li, Yue Ming, Li Li, Rui Ni, Jianhong Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Oncology
Subjects:
cyclovirobuxine D (CVBD)
glioblastoma (GBM)
apoptosis
mitochondrial damage
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.656184/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.656184/full

Similar Items