Voltage Preconditioning Allows Modulated Gene Expression in Neurons Using PEI-complexed siRNA

Voltage Preconditioning Allows Modulated Gene Expression in Neurons Using PEI-complexed siRNA

We present here a high efficiency, high viability siRNA-delivery method using a voltage-controlled chemical transfection strategy to achieve modulated delivery of polyethylenimine (PEI) complexed with siRNA in an in vitro culture of neuro2A cells and neurons. Low voltage pulses were applied to adher...

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Bibliographic Details
Main Authors: Arati Sridharan, Chetan Patel, Jit Muthuswamy
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
controlled dosage
electrical preconditioning
primary neurons
siRNA
tunable transfection
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116301354

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http://www.sciencedirect.com/science/article/pii/S2162253116301354

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