Chitosan Rate of Uptake in HEK293 Cells is Influenced by Soluble versus Microparticle State and Enhanced by Serum-Induced Cell Metabolism and Lactate-Based Media Acidification

Chitosan Rate of Uptake in HEK293 Cells is Influenced by Soluble versus Microparticle State and Enhanced by Serum-Induced Cell Metabolism and Lactate-Based Media Acidification

Chitosan is a biocompatible polysaccharide composed of glucosamine and N-acetylglucosamine. The polymer has a unique behavior of fluctuating between soluble chains at pH 6 and insoluble microparticles at pH 7. The purpose of this study was to test the hypothesis that chitosan structure, solubility s...

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Bibliographic Details
Main Authors: Marc Lavertu, Mario Jolicoeur, Geneviève Lavallée, Nicolas Tran-Khanh, Jessica Guzmán-Morales, Caroline D. Hoemann
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Molecules
Subjects:
chitosan
HEK293 cells
lactate
EGF
serum
confocal microscopy
microparticle
Online Access:http://www.mdpi.com/1420-3049/18/1/1015

Internet

http://www.mdpi.com/1420-3049/18/1/1015

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