Consistent apparent Young’s modulus of human embryonic stem cells and derived cell types stabilized by substrate stiffness regulation promotes lineage specificity maintenance

Consistent apparent Young’s modulus of human embryonic stem cells and derived cell types stabilized by substrate stiffness regulation promotes lineage specificity maintenance

Abstract Background Apparent Young’s modulus (AYM), which reflects the fundamental mechanical property of live cells measured by atomic force microscopy and is determined by substrate stiffness regulated cytoskeletal organization, has been investigated as potential indicators of cell fate in specifi...

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Bibliographic Details
Main Authors: Anqi Guo, Bingjie Wang, Cheng Lyu, Wenjing Li, Yaozu Wu, Lu Zhu, Ran Bi, Chenyu Huang, Jiao Jiao Li, Yanan Du
Format: Article
Language:English
Published: SpringerOpen 2020-09-01
Series:Cell Regeneration
Subjects:
Apparent Young’s modulus
Human embryonic stem cells
Substrate stiffness
YAP
Cell fate
Online Access:http://link.springer.com/article/10.1186/s13619-020-00054-4

Internet

http://link.springer.com/article/10.1186/s13619-020-00054-4

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