Unexpected Gating Behaviour of an Engineered Potassium Channel Kir

Unexpected Gating Behaviour of an Engineered Potassium Channel Kir

In this study, we investigated the dynamics and functional characteristics of the KirBac3.1 S129R, a mutated bacterial potassium channel for which the inner pore-lining helix (TM2) was engineered so that the bundle crossing is trapped in an open conformation. The structure of this channel has been p...

Full description

Bibliographic Details
Main Authors: Charline Fagnen, Ludovic Bannwarth, Dania Zuniga, Iman Oubella, Rita De Zorzi, Eric Forest, Rosa Scala, Samuel Guilbault, Saïd Bendahhou, David Perahia, Catherine Vénien-Bryan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
molecular dynamics and normal modes
HDX-mass spectrometry
single channel recording
potassium channel KirBac3.1
mutation effect
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.691901/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.691901/full

Similar Items