N-Palmitoylethanolamine Maintains Local Lipid Homeostasis to Relieve Sleep Deprivation–Induced Dry Eye Syndrome

N-Palmitoylethanolamine Maintains Local Lipid Homeostasis to Relieve Sleep Deprivation–Induced Dry Eye Syndrome

Sleep loss is a key factor associated with dry eye. Use of a “stick over water” mouse model revealed that sleep deprivation induces accumulation of lipids, hypertrophy, and dysfunction of the lacrimal gland. These changes result in decreased tear production and dry eye clinical signs. The specific p...

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Bibliographic Details
Main Authors: Qi Chen, Chunyan Ji, Ruihe Zheng, Longhe Yang, Jie Ren, Yitian Li, Yun Han, Pan Zhou, Zuguo Liu, Yan Qiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
palmitoylethanolamide
lacrimal gland
lipid accumulation
dry eye
peroxisome proliferator-activated receptor-α
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01622/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01622/full

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