Revealing how an adenylate cyclase toxin uses bait and switch tactics in its activation.

Dissecting how bacterial pathogens escape immune destruction and cause respiratory infections in humans is a work in progress. One tactic employed by microbes is to use bacterial adenylate cyclase toxins (ACTs) to disarm immune cells and disrupt cellular signaling in host cells, which facilitates th...

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Bibliographic Details
Main Author: Natosha L Finley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-02-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC5844667?pdf=render