Extensive Inter-Cyst DNA Methylation Variation in Autosomal Dominant Polycystic Kidney Disease Revealed by Genome Scale Sequencing

Extensive Inter-Cyst DNA Methylation Variation in Autosomal Dominant Polycystic Kidney Disease Revealed by Genome Scale Sequencing

Autosomal dominant polycystic kidney disease (ADPKD) is a heritable disease characterized by bilateral renal enlargement due to the growth of cysts throughout the kidneys. Inheritance of a disease-causing mutation is required to develop ADPKD, which results in end-stage kidney disease and is associa...

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Bibliographic Details
Main Authors: Sarah A. Bowden, Peter A. Stockwell, Euan J. Rodger, Matthew F. Parry, Michael R. Eccles, Cherie Stayner, Aniruddha Chatterjee
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Genetics
Subjects:
polycystic kidney
DNA methylation
autosomal dominant polycystic kidney disease
reduced representation bisulfite sequencing
epigenetics
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00348/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2020.00348/full

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