Lipoxin A4 Restores Septic Renal Function via Blocking Crosstalk Between Inflammation and Premature Senescence

Lipoxin A4 Restores Septic Renal Function via Blocking Crosstalk Between Inflammation and Premature Senescence

Acute kidney injury (AKI) occurs in half of patients with septic shock, resulting in unacceptably high mortality. However, effective preventive treatments are still lacking. We hypothesized that pretreatment with lipoxin A4 (LXA4), known to promote inflammation resolution, may attenuate septic AKI v...

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Bibliographic Details
Main Authors: Chaojin Chen, Rongzong Qiu, Jing Yang, Qian Zhang, Guoliang Sun, Xiaofeng Gao, Ziqing Hei, Haocong Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Immunology
Subjects:
acute kidney injury
sepsis
lipoxin A4
inflammation resolution
cellular senescence
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.637753/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.637753/full

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