DISC1 knockdown impairs the tangential migration of cortical interneurons by affecting the actin cytoskeleton

DISC1 knockdown impairs the tangential migration of cortical interneurons by affecting the actin cytoskeleton

Disrupted-in-Schizophrenia 1 (DISC1) is a risk gene for a spectrum of major mental disorders. It has been shown to regulate radial migration as well as dendritic arborization during neurodevelopment and corticogenesis. In a previous study we demonstrated through in vitro experiments that DISC1 also...

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Bibliographic Details
Main Authors: André eSteinecke, Christin eGampe, Falk eNitzsche, Jürgen eBolz
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-07-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Schizophrenia
Akt
DISC1
Cortical development
cortical interneuron migration
soma translocation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00190/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00190/full

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