Amphotericin B Specifically Induces the Two-Component System LnrJK: Development of a Novel Whole-Cell Biosensor for the Detection of Amphotericin-Like Polyenes

Amphotericin B Specifically Induces the Two-Component System LnrJK: Development of a Novel Whole-Cell Biosensor for the Detection of Amphotericin-Like Polyenes

The rise of drug-resistant fungal pathogens urges for the development of new tools for the discovery of novel antifungal compounds. Polyene antibiotics are potent agents against fungal infections in humans and animals. They inhibit the growth of fungal cells by binding to sterols in the cytoplasmic...

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Bibliographic Details
Main Authors: Ainhoa Revilla-Guarinos, Franziska Dürr, Philipp F. Popp, Maximilian Döring, Thorsten Mascher
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Microbiology
Subjects:
amphotericin
antifungal polyenes
drug discovery
fungal infections
nystatin
stress response
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2020.02022/full

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https://www.frontiersin.org/article/10.3389/fmicb.2020.02022/full

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