Sirolimus Suppresses Phosphorylation of Cofilin and Reduces Interstitial Septal Thickness in Sporadic Lymphangioleiomyomatosis

Sirolimus Suppresses Phosphorylation of Cofilin and Reduces Interstitial Septal Thickness in Sporadic Lymphangioleiomyomatosis

Sporadic lymphangioleiomyomatosis (S-LAM) is a rare lung disease characterized by the proliferation of smooth muscle-like LAM cells and progressive cystic destruction. Sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has a proven efficacy in patients with LAM. However, the therapeutic me...

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Bibliographic Details
Main Authors: Yen-Lin Huang, Po-Ru Chen, Ying-Ju Lai, Hsao-Hsun Hsu
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
lymphangioleiomyomatosis
sirolimus
p-cofilin
interstitial septal thickness
mTOR
Online Access:https://www.mdpi.com/1422-0067/22/16/8564

Internet

https://www.mdpi.com/1422-0067/22/16/8564

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