Cholesterol synthesis inhibition promotes axonal regeneration in the injured central nervous system

Cholesterol synthesis inhibition promotes axonal regeneration in the injured central nervous system

Neuronal regeneration in the injured central nervous system is hampered by multiple extracellular proteins. These proteins exert their inhibitory action through interactions with receptors that are located in cholesterol rich compartments of the membrane termed lipid rafts. Here we show that cholest...

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Bibliographic Details
Main Authors: Alireza P. Shabanzadeh, Jason Charish, Nardos G. Tassew, Nahal Farhani, Jinzhou Feng, Xinjue Qin, Shuzo Sugita, Andrea J. Mothe, Thomas Wälchli, Paulo D. Koeberle, Philippe P. Monnier
Format: Article
Language:English
Published: Elsevier 2021-03-01
Series:Neurobiology of Disease
Subjects:
Cholesterol inhibition
Axonal regeneration
Neuronal survival
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000085

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http://www.sciencedirect.com/science/article/pii/S0969996121000085

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