Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet

Prolyl Endopeptidase Gene Disruption Improves Gut Dysbiosis and Non-alcoholic Fatty Liver Disease in Mice Induced by a High-Fat Diet

The gut-liver axis is increasingly recognized as being involved in the pathogenesis and progression of non-alcoholic fatty liver disease (NAFLD). Prolyl endopeptidase (PREP) plays a role in gut metabolic homeostasis and neurodegenerative diseases. We investigated the role of PREP disruption in the c...

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Bibliographic Details
Main Authors: Daixi Jiang, Jianbin Zhang, Shuangzhe Lin, Yuqin Wang, Yuanwen Chen, Jiangao Fan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
liver
gut microbiota
non-alcoholic fatty liver disease (NAFLD)
gene knockout
prolyl endopeptidase
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.628143/full

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https://www.frontiersin.org/articles/10.3389/fcell.2021.628143/full

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