Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation.

Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation.

The Polo-Like Kinase 1 (PLK1) acts as a central regulator of mitosis and is over-expressed in a wide range of human tumours where high levels of expression correlate with a poor prognosis. PLK1 comprises two structural elements, a kinase domain and a polo-box domain (PBD). The PBD binds phosphorylat...

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Bibliographic Details
Main Authors: David J Huggins, Grahame J McKenzie, Daniel D Robinson, Ana J Narváez, Bryn Hardwick, Meredith Roberts-Thomson, Ashok R Venkitaraman, Guy H Grant, Mike C Payne
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-08-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20711360/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20711360/pdf/?tool=EBI

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