The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.

The Mitochondrial Unfoldase-Peptidase Complex ClpXP Controls Bioenergetics Stress and Metastasis.

Mitochondria must buffer the risk of proteotoxic stress to preserve bioenergetics, but the role of these mechanisms in disease is poorly understood. Using a proteomics screen, we now show that the mitochondrial unfoldase-peptidase complex ClpXP associates with the oncoprotein survivin and the respir...

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Bibliographic Details
Main Authors: Jae Ho Seo, Dayana B Rivadeneira, M Cecilia Caino, Young Chan Chae, David W Speicher, Hsin-Yao Tang, Valentina Vaira, Silvano Bosari, Alessandro Palleschi, Paolo Rampini, Andrew V Kossenkov, Lucia R Languino, Dario C Altieri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-07-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1002507

Internet

https://doi.org/10.1371/journal.pbio.1002507

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