Preparation of (177Lu-DOTA)n-PAMAM-[Nimotuzumab-F(ab’)2] as a Therapeutic Radioimmunoconjugate for EGFR Overexpressed Cancer Treatment

Preparation of (177Lu-DOTA)n-PAMAM-[Nimotuzumab-F(ab’)2] as a Therapeutic Radioimmunoconjugate for EGFR Overexpressed Cancer Treatment

Intact monoclonal antibodies with a high molecular weight tend to have a poor pharmacokinetic profile and tumor penetration, and potential for eliciting host antibody responses. F(ab’)2 fragments smaller than intact monoclonal antibodies that still maintain antigen binding could solve this problem....

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Bibliographic Details
Main Authors: Titis Sekar Humani, Sutari, Triningsih, Martalena Ramli, Rien Ritawidya, Ratna Dini Haryuni
Format: Article
Language:English
Published: ITB Journal Publisher 2017-12-01
Series:Journal of Mathematical and Fundamental Sciences
Subjects:
dendrimer PAMAM
EGFR
nimotuzumab-F(ab’)2
pepsin digestion
177Lu-DOTA-PAMAM-[nimotuzumab-F(ab’)2]
Online Access:http://journals.itb.ac.id/index.php/jmfs/article/view/2375

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