Preparation of (177Lu-DOTA)n-PAMAM-[Nimotuzumab-F(ab’)2] as a Therapeutic Radioimmunoconjugate for EGFR Overexpressed Cancer Treatment

Preparation of (177Lu-DOTA)n-PAMAM-[Nimotuzumab-F(ab’)2] as a Therapeutic Radioimmunoconjugate for EGFR Overexpressed Cancer Treatment

Intact monoclonal antibodies with a high molecular weight tend to have a poor pharmacokinetic profile and tumor penetration, and potential for eliciting host antibody responses. F(ab’)2 fragments smaller than intact monoclonal antibodies that still maintain antigen binding could solve this problem....

Full description

Bibliographic Details
Main Authors: Titis Sekar Humani, Sutari, Triningsih, Martalena Ramli, Rien Ritawidya, Ratna Dini Haryuni
Format: Article
Language:English
Published: ITB Journal Publisher 2017-12-01
Series:Journal of Mathematical and Fundamental Sciences
Subjects:
dendrimer PAMAM
EGFR
nimotuzumab-F(ab’)2
pepsin digestion
177Lu-DOTA-PAMAM-[nimotuzumab-F(ab’)2]
Online Access:http://journals.itb.ac.id/index.php/jmfs/article/view/2375

Internet

http://journals.itb.ac.id/index.php/jmfs/article/view/2375

Similar Items