Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice

Progranulin deficiency exacerbates spinal cord injury by promoting neuroinflammation and cell apoptosis in mice

Abstract Purpose Spinal cord injury (SCI) often results in significant and catastrophic dysfunction and disability and imposes a huge economic burden on society. This study aimed to determine whether progranulin (PGRN) plays a role in the progressive damage following SCI and evaluate the potential f...

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Bibliographic Details
Main Authors: Chao Wang, Lu Zhang, Jean De La Croix Ndong, Aubryanna Hettinghouse, Guodong Sun, Changhong Chen, Chen Zhang, Ronghan Liu, Chuan-ju Liu
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Neuroinflammation
Subjects:
Progranulin
Inflammation
Apoptosis
Spinal cord injury
Online Access:http://link.springer.com/article/10.1186/s12974-019-1630-1

Internet

http://link.springer.com/article/10.1186/s12974-019-1630-1

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