Aptamer-mediated transcriptional gene silencing of Foxp3 inhibits regulatory T cells and potentiates antitumor response

Aptamer-mediated transcriptional gene silencing of Foxp3 inhibits regulatory T cells and potentiates antitumor response

The inhibition of immunosuppressive mechanisms may switch the balance between tolerance and surveillance, leading to an increase in antitumor activity. Regulatory T cells play an important role in the control of immunosuppression, exhibiting the unique property of inhibiting T cell proliferation. Th...

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Bibliographic Details
Main Authors: Andrea J. Manrique-Rincón, Luciana P. Ruas, Carolinne T. Fogagnolo, Randall J. Brenneman, Alexey Berezhnoy, Bianca Castelucci, Sílvio R. Consonni, Eli Gilboa, Marcio C. Bajgelman
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
aptamer
transcriptional gene silencing
FoxP3
Treg
immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001219

Internet

http://www.sciencedirect.com/science/article/pii/S2162253121001219

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