Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function

Linker Histone H1.2 Directs Genome-wide Chromatin Association of the Retinoblastoma Tumor Suppressor Protein and Facilitates Its Function

The retinoblastoma tumor suppressor protein pRb is a master regulator of cellular proliferation, principally through interaction with E2F and regulation of E2F target genes. Here, we describe the H1.2 linker histone as a major pRb interaction partner. We establish that H1.2 and pRb are found in a ch...

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Bibliographic Details
Main Authors: Shonagh Munro, Edward S. Hookway, Melanie Floderer, Simon M. Carr, Rebecca Konietzny, Benedikt M. Kessler, Udo Oppermann, Nicholas B. La Thangue
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Cell Reports
Subjects:
linker histone
retinoblastoma protein
E2F
transcription
cell cycle
chromatin
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717307106

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http://www.sciencedirect.com/science/article/pii/S2211124717307106

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