scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells

Relationships between DNA methylation and transcription, and methylation and DNA accessibility can be probed but interrogating all three in the same single cells has not been possible. Here, the authors report the first single-cell method for parallel chromatin accessibility, DNA methylation and tra...

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Bibliographic Details
Main Authors: Stephen J. Clark, Ricard Argelaguet, Chantriolnt-Andreas Kapourani, Thomas M. Stubbs, Heather J. Lee, Celia Alda-Catalinas, Felix Krueger, Guido Sanguinetti, Gavin Kelsey, John C. Marioni, Oliver Stegle, Wolf Reik
Format: Article
Language:English
Published: Nature Publishing Group 2018-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03149-4

Internet

https://doi.org/10.1038/s41467-018-03149-4

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