NAMPT-Mediated NAD+ Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice

NAMPT-Mediated NAD+ Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice

Obesity is associated with adipose tissue dysfunction and multi-organ insulin resistance. However, the mechanisms of such obesity-associated systemic metabolic complications are not clear. Here, we characterized mice with adipocyte-specific deletion of nicotinamide phosphoribosyltransferase (NAMPT),...

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Bibliographic Details
Main Authors: Kelly L. Stromsdorfer, Shintaro Yamaguchi, Myeong Jin Yoon, Anna C. Moseley, Michael P. Franczyk, Shannon C. Kelly, Nathan Qi, Shin-ichiro Imai, Jun Yoshino
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Subjects:
adipocyte
NAMPT
NAD+
insulin resistance
obesity
PPARγ
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716309457

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http://www.sciencedirect.com/science/article/pii/S2211124716309457

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