α1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice

α1A-adrenaline receptors in dorsal horn inhibitory neurons have an inhibitory role in the regulation of chloroquine-induced itch in mice

Abstract Our previous study showed the intrinsic ability of descending noradrenergic neurons projecting from the locus coeruleus to the spinal dorsal horn (SDH) to suppress itch-related behaviors. Noradrenaline and α1A-adrenaline receptor (α1A-AR) agonist increase inhibitory synaptic inputs onto SDH...

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Bibliographic Details
Main Authors: Yuto Shiraishi, Keisuke Koga, Ryo Yamagata, Izuho Hatada, Miho Shiratori-Hayashi, Makoto Tsuda
Format: Article
Language:English
Published: BMC 2021-03-01
Series:Molecular Brain
Subjects:
α1A-Adrenaline receptor
Spinal dorsal horn
Inhibitory interneurons
Itch
Mouse
Online Access:https://doi.org/10.1186/s13041-021-00768-9

Internet

https://doi.org/10.1186/s13041-021-00768-9

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