Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer

Disruption of TFIIH activities generates a stress gene expression response and reveals possible new targets against cancer

Disruption of the enzymatic activities of the transcription factor TFIIH by the small molecules Triptolide (TPL) or THZ1 could be used against cancer. Here, we used the MCF10A-ErSrc oncogenesis model to compare the effect of TFIIH inhibitors between transformed cells and their progenitors. We report...

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Bibliographic Details
Main Authors: Maritere Uriostegui-Arcos, Rodrigo Aguayo-Ortiz, María del Pilar Valencia-Morales, Erika Melchy-Pérez, Yvonne Rosenstein, Laura Dominguez, Mario Zurita
Format: Article
Language:English
Published: The Royal Society 2020-06-01
Series:Open Biology
Subjects:
tfiih
cancer
transcription
gene expression
rna polymerase ii
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200050

Internet

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200050

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