A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity

A novel derivative of picolinic acid induces endoplasmic reticulum stress-mediated apoptosis in human non-small cell lung cancer cells: synthesis, docking study, and anticancer activity

Thirteen new derivatives of picolinic acid (4–7) were designed and synthesized from the starting parent molecule, picolinic acid. The new compounds were characterized by ATR-FTIR, 1HNMR, and CHNS analysis. A molecular docking study was performed to evaluate the binding affinity of the synthesized co...

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Bibliographic Details
Main Authors: Ali H. Abbas, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Zainab A. Al-Mazaydeh, Majdoleen S. Rammaha, Fatima Alsoubani, Rheda I. Al-bayati
Format: Article
Language:English
Published: Pensoft Publishers 2021-09-01
Series:Pharmacia
Online Access:https://pharmacia.pensoft.net/article/70654/download/pdf/

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