Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening

Discovery of Natural Products as Novel and Potent FXR Antagonists by Virtual Screening

Farnesoid X receptor (FXR) is a member of nuclear receptor family involved in multiple physiological processes through regulating specific target genes. The critical role of FXR as a transcriptional regulator makes it a promising target for diverse diseases, especially those related to metabolic dis...

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Bibliographic Details
Main Authors: Yanyan Diao, Jing Jiang, Shoude Zhang, Shiliang Li, Lei Shan, Jin Huang, Weidong Zhang, Honglin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Chemistry
Subjects:
FXR
antagonist
virtual screening
molecular docking
similarity searching
natural product
Online Access:http://journal.frontiersin.org/article/10.3389/fchem.2018.00140/full

Internet

http://journal.frontiersin.org/article/10.3389/fchem.2018.00140/full

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