Enhanced efficacy of 5-fluorouracil in combination with a dual histone deacetylase and phosphatidylinositide 3-kinase inhibitor (CUDC-907) in colorectal cancer cells

Enhanced efficacy of 5-fluorouracil in combination with a dual histone deacetylase and phosphatidylinositide 3-kinase inhibitor (CUDC-907) in colorectal cancer cells

Background/Aims: 5-Fluorouracil (5-FU) is widely used in the treatment of patients with colorectal cancer (CRC). However, the efficacy of 5-FU as a single agent is limited, with multiple undesired side effects. Therefore, the aim of the current study was to assess the efficacy of CUDC-907 (a dual in...

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Bibliographic Details
Main Authors: Rimi Hamam, Dalia Ali, Radhakrishnan Vishnubalaji, Zaid F Alsaaran, Elna Paul Chalisserry, Musaad Alfayez, Abdullah Aldahmash, Nehad M Alajez
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2017-01-01
Series:The Saudi Journal of Gastroenterology
Subjects:
Colorectal cancer
histone deacetylase inhibitors
phosphatidylinositide 3-kinase
Online Access:http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2017;volume=23;issue=1;spage=34;epage=38;aulast=Hamam

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http://www.saudijgastro.com/article.asp?issn=1319-3767;year=2017;volume=23;issue=1;spage=34;epage=38;aulast=Hamam

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