FOLFOX Chemotherapy Ameliorates CD8 T Lymphocyte Exhaustion and Enhances Checkpoint Blockade Efficacy in Colorectal Cancer

FOLFOX Chemotherapy Ameliorates CD8 T Lymphocyte Exhaustion and Enhances Checkpoint Blockade Efficacy in Colorectal Cancer

Background: Colorectal cancer (CRC) is the third most common malignancy worldwide. The presence of CD8 tumor-infiltrating T lymphocytes (TILs) is associated with improved prognosis and therapeutic response in CRC patients. FOLFOX chemotherapy is a standard first-line treatment for patients with CRC....

Full description

Bibliographic Details
Main Authors: Yue Guan, Sean G. Kraus, Michael J. Quaney, Mark A. Daniels, Jonathan B. Mitchem, Emma Teixeiro
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
chemotherapy
colorectal cancer
CTL
TIL
exhaustion
immune checkpoint blockade
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00586/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00586/full

Similar Items