Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

Human Beta Cells Produce and Release Serotonin to Inhibit Glucagon Secretion from Alpha Cells

In the pancreatic islet, serotonin is an autocrine signal increasing beta cell mass during metabolic challenges such as those associated with pregnancy or high-fat diet. It is still unclear whether serotonin is relevant for regular islet physiology and hormone secretion. Here, we show that human bet...

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Bibliographic Details
Main Authors: Joana Almaça, Judith Molina, Danusa Menegaz, Alexey N. Pronin, Alejandro Tamayo, Vladlen Slepak, Per-Olof Berggren, Alejandro Caicedo
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Cell Reports
Subjects:
serotonin
beta cell
insulin secretion
alpha cell
glucagon secretion
pancreatic islet
paracrine signal
diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716316461

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http://www.sciencedirect.com/science/article/pii/S2211124716316461

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