Protection from noise-induced cochlear synaptopathy by virally mediated overexpression of NT3
Abstract Noise exposures causing only transient threshold shifts can destroy auditory-nerve synapses without damaging hair cells. Here, we asked whether virally mediated neurotrophin3 (NT3) overexpression can repair this damage. CBA/CaJ mice at 6 wks were injected unilaterally with adeno-associated...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-10-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-019-51724-6 |