Anti-Melanogenic Activity of Gagunin D, a Highly Oxygenated Diterpenoid from the Marine Sponge Phorbas sp., via Modulating Tyrosinase Expression and Degradation

Anti-Melanogenic Activity of Gagunin D, a Highly Oxygenated Diterpenoid from the Marine Sponge Phorbas sp., via Modulating Tyrosinase Expression and Degradation

Tyrosinase is the rate-limiting enzyme critical for melanin synthesis and controls pigmentation in the skin. The inhibition of tyrosinase is currently the most common approach for the development of skin-whitening cosmetics. Gagunin D (GD), a highly oxygenated diterpenoid isolated from the marine sp...

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Bibliographic Details
Main Authors: Ho Yeon Lee, Eun Jeong Jang, Song Yi Bae, Ju-eun Jeon, Hyen Joo Park, Jongheon Shin, Sang Kook Lee
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:Marine Drugs
Subjects:
Gagunin D
melanogenesis
tyrosinase
melan-a
Online Access:http://www.mdpi.com/1660-3397/14/11/212

Internet

http://www.mdpi.com/1660-3397/14/11/212

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