8-Oxoguanine DNA Glycosylase (OGG1) Cys326 Variant: Increased Risk for Worse Outcome of Patients with Locally Advanced Rectal Cancer after Multimodal Therapy

8-Oxoguanine DNA Glycosylase (OGG1) Cys326 Variant: Increased Risk for Worse Outcome of Patients with Locally Advanced Rectal Cancer after Multimodal Therapy

Despite excellent loco-regional control by multimodal treatment of locally advanced rectal cancer, a substantial portion of patients succumb to this disease. As many treatment effects are mediated via reactive oxygen species (ROS), we evaluated the effect of single nucleotide polymorphisms (SNPs) in...

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Bibliographic Details
Main Authors: Martin Leu, Theresa Riebeling, Leif Hendrik Dröge, Laura Hubert, Manuel Guhlich, Hendrik Andreas Wolff, Jürgen Brockmöller, Jochen Gaedcke, Stefan Rieken, Markus Anton Schirmer
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Cancers
Subjects:
rectal cancer
neoadjuvant radiochemotherapy
reactive oxygen species
ROS
base excision repair
BER
Online Access:https://www.mdpi.com/2072-6694/13/11/2805

Internet

https://www.mdpi.com/2072-6694/13/11/2805

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