Impact of drug loading in mesoporous silica-amorphous formulations on the physical stability of drugs with high recrystallization tendency

In this study, a method is described to determine the monolayer loading capacity (MLC) of the drugs naproxen and ibuprofen, both having high recrystallization tendencies, in mesoporous silica (MS), a well known carrier that is able to stabilize the amorphous form of a drug. The stabilization has bee...

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Bibliographic Details
Main Authors: Rayane S.C.M.Q. Antonino, Michael Ruggiero, Zihui Song, Thais Leite Nascimento, Eliana Martins Lima, Adam Bohr, Matthias Manne Knopp, Korbinian Löbmann
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:International Journal of Pharmaceutics: X
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156719300404