ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis

ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis

Patients with pulmonary alveolar proteinosis (PAP) display impaired surfactant clearance, foamy, lipid-filled alveolar macrophages, and increased cholesterol metabolites within the lung. Neutralizing autoantibodies to granulocyte-macrophage colony-stimulating factor (GM-CSF) are also present, result...

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Bibliographic Details
Main Authors: Mary Jane Thomassen, Barbara P. Barna, Achut G. Malur, Tracey L. Bonfield, Carol F. Farver, Anagha Malur, Heidi Dalrymple, Mani S. Kavuru, Maria Febbraio
Format: Article
Language:English
Published: Elsevier 2007-12-01
Series:Journal of Lipid Research
Subjects:
liver X receptor α
peroxisome proliferator-activated receptor γ
ATP binding cassette transporter A1
ATP binding cassette transporter G1
foam cells
granulocyte-macrophage colony-stimulating factor
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520429268

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http://www.sciencedirect.com/science/article/pii/S0022227520429268

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