MET alterations detected in blood-derived circulating tumor DNA correlate with bone metastases and poor prognosis

MET alterations detected in blood-derived circulating tumor DNA correlate with bone metastases and poor prognosis

Abstract Background We analyzed clinical associations of MET alterations in the plasma of patients with diverse malignancies. Methods Digital sequencing of circulating tumor DNA (ctDNA) (54–70 genes) was performed in 438 patients; 263 patients also had tissue sequencing (182–315 genes). The most rep...

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Bibliographic Details
Main Authors: Sadakatsu Ikeda, Maria Schwaederle, Mandakini Mohindra, Denis L. Fontes Jardim, Razelle Kurzrock
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Hematology & Oncology
Subjects:
MET
ctDNA
cfDNA
Liquid biopsies
Bone metastasis
Online Access:http://link.springer.com/article/10.1186/s13045-018-0610-8

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http://link.springer.com/article/10.1186/s13045-018-0610-8

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