Trisomy of chromosome 8 in Ph-negative cells of the bone marrow in patients with chronic myeloid leukemia treated with inhibitors of BCR-ABL tyrosinkinases

Trisomy of chromosome 8 in Ph-negative cells of the bone marrow in patients with chronic myeloid leukemia treated with inhibitors of BCR-ABL tyrosinkinases

Aim. To analyse clinical implications of chromosome 8 trisomy in Ph-negative cells of the bone marrow in patients with chronic myeloid leukemia (CML) treated with inhibitors of tyrosinkinases (ITK). Material and methods. A total of 386 patients with CML (chronic phase - 288, acceleration phase - 77)...

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Main Authors: Anna Grigor'evna Turkina, Elena Vasil'evna Domracheva, Aleksandra Valer'evna Vorontsova, Elena Aleksandrovna Aseeva, Ol'ga Yur'evna Vinogradova, Ol'ga Veniaminovna Stakhina, Galina Anatol'evna Gusarova, Ol'ga Arkad'evna Dyagileva, Elena Aleksandrovna Semenova, Marina Vasil'evna Vakhrusheva, Tamara Ivanovna Kolosheynova, Evgeniy Mikhaylovich Abakumov, Ekaterina Yur'evna Chelysheva, Svetlana Rudol'fovna Goryacheva, Tat'yana Vladimirovna Ivanova, Elena Stanislavovna Zakharova, Lyubov' Yur'evna Kolosova, Adel' Vladimirovna Zakharova, Irina Nikolaevna Naumova, Larisa Vladimirovna Dyachenko, Sergey Mikhaylovich Kulikov, Lidiya Grigor'evna Kovaleva, Nina Dmitrievna Khoroshko, A G Turkina, E V Domracheva, A V Vorontsova, E A Aseeva, O Yu Vinogradova, O V Stakhina, G A Gusarova, O A Dyagileva, E A Semenova, M V Vakhrusheva, T I Kolosheinova, E M Abakumov, E Yu Chelysheva, S R Goryacheva, T V Ivanova, E S Zakharova, L Yu Kolosova, A V Zakharova, I N Naumova, L V Dyachenko, S M Kulikov, L G Kovaleva, N D Khoroshko
Format: Article
Language:Russian
Published: "Consilium Medicum" Publishing house 2009-07-01
Series:Терапевтический архив
Subjects:
chronic myeloid leukemia
chromosome 8 trisomy
ph-negative cells
inhibitors of bcr-abl tyrosinkinase
Online Access:https://ter-arkhiv.ru/0040-3660/article/view/30364

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https://ter-arkhiv.ru/0040-3660/article/view/30364

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