Increased Nitroxidative Stress Promotes Mitochondrial Dysfunction in Alcoholic and Nonalcoholic Fatty Liver Disease

Increased nitroxidative stress causes mitochondrial dysfunctions through oxidative modifications of mitochondrial DNA, lipids, and proteins. Persistent mitochondrial dysfunction sensitizes the target cells/organs to other pathological risk factors and thus ultimately contributes to the development o...

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Bibliographic Details
Main Authors: Byoung-Joon Song, Mohamed A. Abdelmegeed, Lauren E. Henderson, Seong-Ho Yoo, Jie Wan, Vishnudutt Purohit, James P. Hardwick, Kwan-Hoon Moon
Format: Article
Language:English
Published: Hindawi Limited 2013-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2013/781050