A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes

A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes

A subset of CpG Island promoter genes are regulated by Polycomb-Repressive Complex 2 (PRC2+-CGI), which become DNA hypermethylated and silenced in cancer. Here, the authors investigate the transcriptomic and epigenomic characteristics of PRC2-occupied CGI and free CGI across pan-cancer types.

Bibliographic Details
Main Authors: Yueyuan Zheng, Guowei Huang, Tiago C. Silva, Qian Yang, Yan-Yi Jiang, H. Phillip Koeffler, De-Chen Lin, Benjamin P. Berman
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22720-0

Internet

https://doi.org/10.1038/s41467-021-22720-0

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