NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis

NSD1- and NSD2-damaging mutations define a subset of laryngeal tumors with favorable prognosis

The authors use an integrative clustering approach to identify two laryngeal cancer clusters with distinct prognosis and show that mutations damaging the NSD1 and NSD2 methyltransferases segregate to the cluster with favorable prognosis, and independently predict longer survival in patients with lar...

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Bibliographic Details
Main Authors: Suraj Peri, Evgeny Izumchenko, Adrian D. Schubert, Michael J. Slifker, Karen Ruth, Ilya G. Serebriiskii, Theresa Guo, Barbara A. Burtness, Ranee Mehra, Eric A. Ross, David Sidransky, Erica A. Golemis
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01877-7

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https://doi.org/10.1038/s41467-017-01877-7

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