Differential regulation of nimodipine-sensitive and -insensitive Ca2+ influx by the Na+/Ca2+ exchanger and mitochondria in the rat suprachiasmatic nucleus neurons

Differential regulation of nimodipine-sensitive and -insensitive Ca2+ influx by the Na+/Ca2+ exchanger and mitochondria in the rat suprachiasmatic nucleus neurons

Abstract Background Transmembrane Ca2+ influx is critical for molecular rhythmicity, metabolic activity, and neuropeptide release in the central clock of the suprachiasmatic nucleus (SCN). We previously reported that both the Na+/Ca2+ exchanger (NCX) and mitochondria play a role in regulating intrac...

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Bibliographic Details
Main Authors: Pi-Cheng Cheng, Yi-Chi Wang, Ya-Shuan Chen, Ruo-Ciao Cheng, Jyh-Jeen Yang, Rong-Chi Huang
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Journal of Biomedical Science
Subjects:
Action potential
Ca2+ channels
Ca2+ imaging
Na+/Ca2+ exchanger
Mitochondria
Suprachiasmatic nucleus
Online Access:http://link.springer.com/article/10.1186/s12929-018-0447-z

Internet

http://link.springer.com/article/10.1186/s12929-018-0447-z

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